Flavanones are important naturally occurring organic compounds possessing a wide range of biological activities, used in the treatment of various diseases. Flavanones are an important member of the flavonoid family that have been receiving increasing attention due to their medicinal properties. The biological activity of flavanones mainly depends on its physical and chemical property. Various analogues of flavanones were synthesized from oxidative cyclization of chalcones. In the present study flavanones were synthesized by claisen–schmidt condensation between benzaldehyde and O-hydroxyacetophenone. Semicarbazide is a derivative of urea and has been known for various reasons with in foods. It occurs as one of the break-down products of nitrofurans, a group of widely used veterinary drugs and as a break-down product of azodicarbonamide, used as a flour treatment agent to improve baking properties. Semicarbazide are the raw material of semicarbazone, have been known to have biological activity against the most common species of bacteria, it is also used as a detection reagent in thin layer chromatography (TLC). Semicarbazide products having antiviral, anti-infective and antineoplastic activities. We synthesized some novel flavanones incorporated Semicarbazide derivatives. The derivatives were characterized by physico-chemical (TLC and melting point) and spectral analysis (I.R., N.M.R and Mass Spectroscopy) and finally the biological activities were performed by using different animal models like pentylenetetrazole-induced convulsions in rats for anti-convulsant and tail immersion method for analgesic activities respectively.
Loading....